Doptelet (10 tab pack) 20 mg tablet

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Medication name

Generic name:
Avatrombopag - oral

Pronunciation
(A-va-TROM-boe-pag)

Brand name(s)
Doptelet

Uses

This medication is used by people with chronic liver disease and a certain blood disorder (low platelet count) who are scheduled to have a medical or dental procedure. Having a low platelet count increases the risk of too much bleeding during certain procedures. This medication increases the production of platelets by your body to help prevent too much bleeding from the procedure.

How to use

Read the Patient Information Leaflet if available from your pharmacist before you start taking avatrombopag and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily for 5 days in a row. Your doctor will tell you how much to take and when to start taking it (usually 10 to 13 days before your procedure). The dosage is based on your medical condition, lab tests, and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side effects

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • symptoms of low sodium blood levels (such as nausea, extreme drowsiness, mental/mood changes)
  • swelling hands/ankles/feet

This medication may rarely cause blood clots (such as pulmonary embolism, stroke, heart attack, deep vein thrombosis). You may be at increased risk for blood clots if you have a history of blood clots, chronic liver disease, certain inherited blood clotting disorders, or if you are immobile (such as on very long plane flights or being bedridden). If you use estrogen-containing products, these may also increase your risk. Before using this medication, if you have any of these conditions report them to your doctor or pharmacist (see also Precautions section). Get medical help right away if any of these side effects occur:

  • shortness of breath/rapid breathing
  • chest/jaw/left arm pain
  • unusual sweating
  • confusion
  • sudden dizziness/fainting
  • pain/swelling/warmth in the groin/calf
  • sudden/severe headaches
  • trouble speaking
  • weakness on one side of the body
  • sudden vision changes
  • stomach/abdominal pain or tenderness

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking avatrombopag, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • blood clotting disorders (such as protein C or protein S deficiency, antithrombin deficiency, Factor V Leiden)

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 2 weeks after the last dose is not recommended. Consult your doctor before breast-feeding.

Drug interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Lab tests (such as platelet count) must be done before you start taking this medication and on the day of the procedure. Other lab/medical tests (such as blood mineral levels) may also be done. Keep all medical and lab appointments.

Missed dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store in the original package at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Medical alert

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Important note

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Information last revised June 2018.

Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.