Overview
A diphtheria and tetanus (Td) vaccine protects people against diphtheria and tetanus (lockjaw). You can get a Td shot every 10 years to help prevent these diseases, which can be fatal.
You may also need a Td booster if you get a puncture wound or dirty cut. A booster is another dose of the vaccine.
Young teens can get a booster at 11 to 12 years of age. This booster is called Tdap and includes the vaccine against pertussis (whooping cough). All teens and adults who never had Tdap also can get one dose of this vaccine.
Common side effects of the Td vaccine include soreness in the arm where you got the shot and a mild fever. These usually occur within 3 days of the shot and last a short time.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and contact your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
How can you care for yourself at home?
- Take an over-the-counter pain medicine, such as acetaminophen (Tylenol), ibuprofen (Advil, Motrin), or naproxen (Aleve), if your arm is sore after the shot. Be safe with medicines. Read and follow all instructions on the label. Teens should not take aspirin. It has been linked to Reye syndrome, a rare but serious illness.
- Do not take two or more pain medicines at the same time unless the doctor told you to. Many pain medicines have acetaminophen, which is Tylenol. Too much acetaminophen (Tylenol) can be harmful.
- Put ice or a cold pack on the area for 10 to 20 minutes at a time. Put a thin cloth between the ice and your skin.
When should you call for help?
Call 911 anytime you think you may need emergency care. For example, call if:
- You have a seizure.
- You have symptoms of a severe allergic reaction. These may include:
- Sudden raised, often discolored areas (hives) all over your body.
- Swelling of the throat, mouth, lips, or tongue.
- Trouble breathing.
- Passing out (losing consciousness). Or you may feel very lightheaded or suddenly feel weak, confused, or restless.
- Severe belly pain, nausea, vomiting, or diarrhea.
Contact your doctor now or seek immediate medical care if:
- You have symptoms of an allergic reaction, such as:
- A rash or hives (raised, often discoloredareas on the skin).
- Itching.
- Swelling.
- Mild belly pain or nausea.
- You have a high fever.
Watch closely for changes in your health, and be sure to contact your doctor if you have any problems.
Where can you learn more?
Go to http://www.healthwise.net/patientEd
Enter V332 in the search box to learn more about "Tetanus and Diphtheria Booster: Care Instructions".
Current as of: February 27, 2026
Author: WebMD Ignite Staff
Clinical Review Board
All WebMD Ignite education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

