Overview
The human papillomavirus (HPV) vaccine protects against HPV. HPV is a common sexually transmitted infection (STI). There are many types of HPV. Some types of the virus can cause genital warts. Other types can cause cervical or oral cancer and some uncommon cancers, such as anal and vaginal cancer.
Age 11 or 12 is when the vaccine is most often given, but it can be given from age 9 to 26. If you are age 27 to 45 and have not been vaccinated for HPV, ask your doctor if getting the vaccine is right for you.
Children ages 9 to 14 get the vaccine in a series of two shots. Some children may get a third dose. Anyone age 15 to 26 gets the vaccine as a three-dose series. Getting all the shots in the series helps the vaccine give the most protection.
The best time to get the vaccine is before a person becomes sexually active. This is because the vaccine works best before there is any chance of infection with HPV. When the vaccine is given at this time, it can prevent almost all infection by the types of HPV the vaccine protects against.
Having the HPV vaccine does not change the schedule for getting Pap tests. If you've had the HPV vaccine, follow the same Pap test schedule as those who haven't had the vaccine.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and contact your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
How can you care for yourself at home?
- Common side effects of getting the vaccine include headache, fever, and redness or swelling at the site of the shot. Take an over-the-counter pain medicine, such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), if you have any of these side effects after the shot. Be safe with medicines. Read and follow all instructions on the label.
- Put ice or a cold pack on the sore area for 10 to 20 minutes at a time. Put a thin cloth between the ice and your skin.
- If you are a parent of a child who's getting the shot, talk to your child about HPV and the vaccine. It's a chance to teach your child about safer sex and sexually transmitted infections (STIs).
When should you call for help?
Call 911 anytime you think you may need emergency care. For example, call if:
- You have symptoms of a severe allergic reaction. These may include:
- Sudden raised, red areas (hives) all over your body.
- Swelling of the throat, mouth, lips, or tongue.
- Trouble breathing.
- Passing out (losing consciousness). Or you may feel very lightheaded or suddenly feel weak, confused, or restless.
- Severe belly pain, nausea, vomiting, or diarrhea.
Contact your doctor now or seek immediate medical care if:
- You have symptoms of an allergic reaction, such as:
- A rash or hives (raised, red areas on the skin).
- Itching.
- Swelling.
- Mild belly pain or nausea.
- You have a fever for more than 1 day.
Watch closely for changes in your health, and be sure to contact your doctor if you have any problems.
Where can you learn more?
Go to http://www.healthwise.net/patientEd
Enter C525 in the search box to learn more about "HPV Vaccine: Care Instructions".
Current as of: September 30, 2025
Author: Ignite Healthwise, LLC Staff
Clinical Review Board
All Ignite Healthwise, LLC education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

