What are upper respiratory infections?
An upper respiratory infection, also called a URI, is an infection of the nose, sinuses, or throat. Viruses or bacteria can cause URIs. Colds, the flu, and sinusitis are examples of URIs. These infections are spread by coughs, sneezes, and close contact. Home treatment is usually all that is needed to feel better.
How do these infections affect COPD?
Colds, COVID-19, the flu, and other upper respiratory infections can cause your COPD symptoms to get worse over a short time and stay bad. This is called a COPD flare-up. Flare-ups are also called exacerbations.
How can you care for yourself?
- To prevent dehydration, drink plenty of fluids. Choose water and other clear liquids until you feel better. If you have kidney, heart, or liver disease and have to limit fluids, talk with your doctor before you increase the amount of fluids you drink.
- Try an over-the-counter pain medicine, such as acetaminophen (Tylenol), ibuprofen (Advil, Motrin), or naproxen (Aleve). Be safe with medicines. Read and follow all instructions on the label. Do not give aspirin to teens. It has been linked to Reye syndrome, a rare but serious illness.
- Be careful when taking over-the-counter cold or flu medicines and Tylenol at the same time. Many of these medicines have acetaminophen, which is Tylenol. Read the labels to make sure that you are not taking more than the recommended dose. Too much acetaminophen (Tylenol) can be harmful.
- Get plenty of rest.
- Use saline (saltwater) nasal washes to help keep your nasal passages open and wash out mucus and allergens. You can buy saline nose sprays at a grocery store or drugstore. Follow the instructions on the package. Or you can make your own nasal wash at home. Add 1 teaspoon of non-iodized salt and 1 teaspoon of baking soda to 2 cups of distilled or boiled and cooled water. Fill a squeeze bottle or neti pot with the homemade nasal wash. Then put the tip into your nostril, and lean over the sink. With your mouth open, gently squirt the liquid. Repeat on the other side.
- Use a vaporizer or humidifier to add moisture to your bedroom. Follow the instructions for cleaning the machine.
- Do not smoke or vape, and avoid being around others who are smoking or vaping. If you need help quitting, talk to your doctor about quit programs and medicines. These can increase your chances of quitting for good.
How can you help prevent upper respiratory infections?
There are several things you can do to help prevent colds and other upper respiratory infections, or URIs:
- Wash your hands often.
- Be extra careful when you're around people with colds.
- Keep your hands away from your face. Your nose, eyes, and mouth are the most likely places for germs to enter your body.
- Eat healthy foods, get plenty of sleep, and exercise. This keeps your body and immune system strong so it can fight URIs.
- Do not smoke or vape, and avoid being around others who are smoking or vaping. Smoking or vaping makes it easier to get a URI and harder to get rid of one. If you need help quitting, talk to your doctor about quit programs and medicines. These can increase your chances of quitting for good.
- Stay up to date on your vaccines. Talk to your doctor about which vaccines are right for you. Vaccines may protect you from serious problems from a respiratory infection.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and contact your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Where can you learn more?
Go to http://www.healthwise.net/patientEd
Enter V912 in the search box to learn more about "Learning About COPD and Upper Respiratory Infections".
Current as of: March 22, 2026
Author: WebMD Ignite Staff
Clinical Review Board
All WebMD Ignite education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

