Learning About Aldosterone Receptor Antagonists

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Aldosterone receptor antagonists are a type of medicine used to treat heart failure and high blood pressure. They're also used for liver disease (cirrhosis) and kidney disease. They may be used for people getting gender-affirming care. They're a type of diuretic, or "water pill." They help your body get rid of extra fluid.


Here are some examples of aldosterone receptor antagonists. For each item in the list, the generic name is first. This is followed by an example of a brand name.

  • eplerenone (Inspra)
  • spironolactone (Aldactone)

Possible side effects

Ask your doctor or pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Some of the side effects include:

  • High potassium levels.
  • Kidney problems.
  • Male breast changes. This may occur when taking spironolactone.

What to know about taking this medicine

Some cautions are:

  • Do not use salt substitutes that have potassium. Some diuretics make your body lose potassium. But this one does not.
  • You may need regular blood tests.
  • You may feel more tired or need to urinate more often when you start to take it. These effects tend to occur less often over time. If the increase in urine gets in the way of your sleep or daily activities, talk to your doctor. They can help you plan a schedule for taking the medicine.
  • Take your medicines exactly as prescribed. Call your doctor if you think you are having a problem with your medicine.
  • Do not take this medicine if you are pregnant, breastfeeding, or planning to become pregnant.
  • Check with your doctor or pharmacist before you use any other medicines. This includes ones you buy over the counter. Make sure your doctor knows all of the medicines you take. And tell your doctor about any vitamins, herbal products, and supplements you take. Taking some medicines together can cause problems.

The Health Encyclopedia contains general health information. Not all treatments or services described are covered benefits for Kaiser Permanente members or offered as services by Kaiser Permanente. For a list of covered benefits, please refer to your Evidence of Coverage or Summary Plan Description. For recommended treatments, please consult with your health care provider.