Mepolizumab - injection
Mepolizumab - injection
This medication is used along with other medications to control and prevent symptoms (such as wheezing and shortness of breath) caused by asthma. Controlling symptoms of asthma helps you do your normal activities and decreases time lost from work or school. Mepolizumab works by reducing swelling (inflammation) of the airways in the lungs to make breathing easier. Mepolizumab is also used to treat a certain immune system disease (eosinophilic granulomatosis with polyangiitis-EGPA). It helps to control and prevent symptoms (such as wheezing, shortness of breath, runny nose, facial pain) caused by the disease. It works by reducing swelling (inflammation) of the blood vessels and also decreasing the amount of certain white blood cells (eosinophils) which may cause the disease.
This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden asthma attacks or breathing problems. If an asthma attack occurs, use your quick-relief inhaler as prescribed.
Read the Patient Information Leaflet if available from your pharmacist before you start using mepolizumab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is given by injection under the skin into the upper arm, thigh, or abdomen by a health care professional. It is given as directed by your doctor, usually once every 4 weeks.
If you are regularly using a corticosteroid medication, you should not stop using it unless directed by your doctor. You may have withdrawal symptoms if the drug is suddenly stopped. Some conditions (such as asthma, allergies) may become worse when the drug is suddenly stopped. To prevent withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may direct you to slowly lower the dose of your corticosteroid medication after you begin using this product. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar when you need to receive it each month.
Tell your doctor if your condition does not get better or if it gets worse.
Pain/redness/swelling at injection site or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including:
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Before using mepolizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Keep all medical and lab appointments.
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.
Not applicable. This medication is given in a hospital or clinic or doctor's office and will not be stored at home.
Information last revised December 2017.
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