Generic name:
Atezolizumab/hyaluronidase - subcutaneous injection
Pronunciation
(A-te-zoe-LIZ-ue-mab/HYE-al-ure-ON-i-dase)
Brand name(s)
Tecentriq Hybreza
Generic name:
Atezolizumab/hyaluronidase - subcutaneous injection
Pronunciation
(A-te-zoe-LIZ-ue-mab/HYE-al-ure-ON-i-dase)
Brand name(s)
Tecentriq Hybreza
This combination medication is used to treat various cancers (such as liver/lung/skin cancer, alveolar soft part sarcoma - ASPS). It contains 2 medications: atezolizumab and hyaluronidase. Atezolizumab belongs to a class of drugs known as monoclonal antibodies. It works by helping your immune system fight the cancer. Hyaluronidase is used to help the body absorb atezolizumab, which helps it work better.
Read the Medication Guide provided by your pharmacist before you start using atezolizumab/hyaluronidase and each time you get a treatment. If you have any questions, ask your doctor or pharmacist.
This medication is given by injection under the skin by a health care professional. It is injected slowly into the thigh over 7 minutes. It is given as directed by your doctor, usually once every 3 weeks.
Injection reactions may happen during the injection of this drug. Tell your doctor right away if you have any symptoms of injection reactions such as chills, itching, shortness of breath, flushing, dizziness, lightheadedness, fever, back/neck pain. Your doctor may give you other medications to help with these side effects or may slow down or stop your treatment for some time.
Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar with a reminder.
See also How to Use section.
Tiredness, loss of appetite, muscle/bone pain, or nausea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including:
This medication may cause hormone gland problems (such as thyroid, pituitary, adrenal, pancreas). Your body could make too much or too little hormone. Tell your doctor right away if you have any symptoms such as:
Get medical help right away if you have any very serious side effects, including:
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using this medication, tell your doctor or pharmacist if you are allergic to atezolizumab or hyaluronidase; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using this medication. Atezolizumab may harm an unborn baby. Ask about reliable forms of birth control while using this medication and for 5 months after the last dose. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug and for 5 months after the last dose. Consult your doctor before breastfeeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669.
Lab and/or medical tests (such as liver/kidney/thyroid function) should be done before you start using this medication and while you are using it. Keep all medical and lab appointments. Consult your doctor for more details.
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.
Not applicable. This medication is given in a hospital or clinic and will not be stored at home.
HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Information last revised September 2024.
Copyright(c) 2024 First Databank, Inc.
Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.
The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.