How insulin works

Multiple insulin medication types are displayed on a table

Your body uses insulin in different ways.

Sometimes you need insulin to quickly lower your blood sugar. Your body also needs insulin on a regular basis to keep your blood sugar in a target range.

Different types of insulin are available to support your specific needs.

A guide to insulin types

Rapid-acting

Generic name: Lispro

Brand name: Humalog

Onset (length of time before insulin reaches your blood): 15 to 30 minutes

Peak (time period when insulin is most effective): 30 minutes to 2 hours

Duration (how long insulin works): 3 to 5 hours

Short-acting

Generic name: Regular

Brand name: Humilin R

Onset (length of time before insulin reaches your blood): 30 to 60 minutes

Peak (time period when insulin is most effective): 2 to 4 hours

Duration (how long insulin works): 5 to 8 hours

Intermediate acting

Generic name: NPH

Brand name: Humulin N

Onset (length of time before insulin reaches your blood): 1 to 2 hours

Peak (time period when insulin is most effective): 4 to 10 hours

Duration (how long insulin works): 12 to 20 hours

Long-acting

Generic name: Giargine

Brand name: Lantus

Onset (length of time before insulin reaches your blood): 1 to 2 hours

Peak (time period when insulin is most effective): Minimal peak

Duration (how long insulin works): Up to 24 hours

Mixed

Generic name: 70/30

Brand name: Humulin 70/30

Onset (length of time before insulin reaches your blood): 30 to 60 minutes

Peak (time period when insulin is most effective): 2 to 10 hours

Duration (how long insulin works): 10 to 16 hours

 

  • Rapid-acting and short-acting insulins are usually given at mealtimes. They lower blood sugar levels quickly and then wear off.

  • Intermediate-acting or long-acting insulins are used to help control blood sugar throughout the day

  • Mixed insulins (a combination of insulin types) are commonly used to keep blood sugar levels normal throughout the day.
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