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Learning About ARNIs (Angiotensin Receptor Neprilysin Inhibitors)

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Overview

Angiotensin receptor neprilysin inhibitors (ARNIs) are a type of medicine that relaxes blood vessels and lowers your blood pressure. It makes it easier for blood to flow through the vessels. It can make it easier for your heart to pump blood.

This medicine may be used to treat heart failure. It may help you feel better, stay out of the hospital, and live longer.

Examples

An example of an ARNI is sacubitril and valsartan (Entresto).

Possible side effects

Ask your doctor or pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine. Common side effects of these medicines include:

  • Feeling lightheaded or dizzy.
  • Low blood pressure. You may feel dizzy and weak.
  • High potassium levels.
  • Cough.
  • Kidney problems.
  • Swelling of your lips, tongue, or face. If the swelling is severe, you may need treatment right away. Severe swelling can make it hard to breathe, but this is rare.

What to know about taking this medicine

Some cautions are:

  • These medicines can cause an allergic reaction. This can cause a little swelling. Or it can cause red bumps on your skin that hurt. In rare cases, the swelling may make it hard for you to breathe.
  • Do not take this medicine if you are pregnant or you plan to become pregnant.
  • Take your medicines exactly as prescribed. Call your doctor if you think you are having a problem with your medicine.
  • Check with your doctor or pharmacist before you use any other medicines. This includes over-the-counter medicines. Make sure your doctor knows all of the medicines, vitamins, herbal products, and supplements you take. Taking some medicines together can cause problems.
  • You may need regular blood tests.

Current as of: June 24, 2023

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

Current as of: June 24, 2023

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

The Health Encyclopedia contains general health information. Not all treatments or services described are covered benefits for Kaiser Permanente members or offered as services by Kaiser Permanente. For a list of covered benefits, please refer to your Evidence of Coverage or Summary Plan Description. For recommended treatments, please consult with your health care provider.