methenamine 120 phos-p.salicy-hyosc 0.12 mg capsule


The photos shown are samples only

Medication name

Generic name:
Methenamine/meth blue/salicylate/acidifier/hyoscyamine - oral

(meth-EN-a-meen/METH-i-leen bloo/sa-LIS-i-late/Acidifier/HYE-oh-SYE-a-meen)

Brand name(s)
Hyophen , Phosphasal , Urelle , Uribel , Urimar-T


This medication is used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by an infection or a medical procedure. Methenamine is an antibacterial drug. Methylene blue is an antiseptic and is related to a group of drugs called monoamine oxidase inhibitors (MAO inhibitors). Both methenamine and methylene blue help to prevent the growth of bacteria in the urine. Salicylate, which is related to aspirin, is a pain reliever. This product also contains an ingredient (such as sodium phosphate, benzoic acid) to make the urine more acidic, which helps methenamine work better. Hyoscyamine is an antispasmodic drug that relaxes the muscles of the urinary tract to relieve cramps/spasms.

This product should not be used to treat a urinary tract infection. If you have a bacterial infection, an antibiotic is usually prescribed to treat it. Consult your doctor for more details.

This medication is not recommended for children younger than 6 years because they are more sensitive to the side effects.

How to use

Take this medication by mouth as directed by your doctor, usually 4 times a day. Take each dose with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking this medication. Drink plenty of fluids while you are being treated with this medication unless otherwise directed by your doctor. If stomach upset occurs with this medication, you may take it with food.

The dosage is based on your medical condition, age, and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Antacids may decrease the absorption and the effectiveness of this product. If you are also taking antacids, take this product at least 1 hour before antacids.

For the best effect, take this medication at evenly spaced times. To help you remember, take it at the same times each day.

Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.

Tell your doctor if your condition does not improve in a few days or if you develop signs of a urinary tract infection (such as burning/painful/frequent urination).

Side effects

Nausea, vomiting, dry mouth, dizziness, drowsiness, blurred vision, or constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

This medication causes urine and sometimes stools to turn blue-green. This effect is harmless and will disappear when the medication is stopped.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • hot/dry/flushed skin
  • decreased sweating
  • eye pain
  • difficult urination
  • signs of kidney problems (such as change in the amount of urine, painful urination)

Get medical help right away if you have any very serious side effects, including:

  • easy bruising/bleeding
  • black/tarry stools
  • stomach/abdominal pain
  • vomit that looks like coffee grounds
  • signs of liver problems (such as nausea/vomiting that doesn't stop, unusual tiredness, dark urine, yellowing eyes/skin)

This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Many drug interactions can increase this risk (see Drug Interactions section). Get medical help right away if any of these serious side effects occur:

  • severe headache
  • fast/slow/irregular/pounding heartbeat
  • chest pain
  • neck stiffness/soreness
  • severe nausea/vomiting
  • sweaty/clammy skin (sometimes with fever)
  • widened pupils
  • vision changes (such as double/blurred vision)
  • sudden sensitivity to light (photophobia)

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before taking this medication, tell your doctor or pharmacist if you are allergic to any of its ingredients; or to aspirin or NSAIDs (such as ibuprofen); or to belladonna alkaloids (such as atropine, scopolamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • kidney problems
  • liver problems
  • urinary blockage problems
  • difficulty urinating (such as due to an enlarged prostate)
  • stomach/intestinal disorders (such as obstruction, ulcers)
  • glaucoma (narrow angle type)
  • heart problems (such as coronary heart disease, heart failure, fast/irregular heartbeat)
  • high blood pressure
  • myasthenia gravis
  • bleeding/clotting problems
  • certain enzyme deficiencies (pyruvate kinase or G6PD deficiency)
  • aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs)
  • growths in the nose (nasal polyps)
  • stroke
  • severe/frequent headaches
  • a certain kind of adrenal gland tumor (pheochromocytoma)
  • dehydration

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Also, limit tobacco and alcohol use to lower the risk of stomach bleeding.

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children are more sensitive to the side effects of this drug, especially unusual excitement, hot/dry/flushed skin, decreased sweating.

This product contains salicylate, which is related to aspirin. Children and teenagers younger than 18 years should not take aspirin or aspirin-related medications if they have chickenpox, flu, or any undiagnosed illness, or if they have recently received a live virus vaccine (such as flu vaccine given in the nose, varicella vaccine), without first consulting the doctor. A rare but serious illness known as Reye's syndrome may occur.

Older adults may be more sensitive to the side effects of this drug, especially confusion, agitation, drowsiness, unusual excitement, constipation, and difficulty urinating. Confusion and drowsiness can increase the risk of falling.

Tell your doctor if you are pregnant or if you plan to become pregnant. This medication may harm an unborn baby and cause problems with normal labor/delivery. It is not recommended for use in pregnancy from 20 weeks until delivery. If your doctor decides that you need to use this medication between 20 and 30 weeks of pregnancy, you should use the lowest effective dose for the shortest possible time. You should not use this medication after 30 weeks of pregnancy. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Drug interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

This medication may interact with many products. Some products include:

  • apraclonidine
  • atomoxetine
  • bupropion
  • carbamazepine
  • dichlorphenamide
  • methotrexate
  • mifepristone
  • potassium capsules/tablets
  • pramlintide
  • tetrabenazine
  • certain Parkinson's disease drugs (entacapone, levodopa, tolcapone)
  • certain high blood pressure drugs (guanethidine, methyldopa)
  • sulfonamide drugs (including sulfa antibiotics such as sulfamethoxazole)
  • sympathomimetics (such as amphetamine, ephedrine)
  • products that decrease the amount of acid in the urine (such as antacids, sodium bicarbonate, potassium/sodium citrate, acetazolamide)

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Taking other MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking other MAO inhibitors (isocarboxazid, linezolid, metaxalone, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using this product, report the use of other drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with this product, including herbal products (such as ephedra/ma huang), nasal decongestants (such as phenylephrine, pseudoephedrine), stimulants (such as amphetamines, ephedrine, epinephrine), diet aids, among others. This product should not be used with any of these medications. Talk to your doctor or pharmacist for more details.

If you are also taking azole antifungal drugs (such as itraconazole, ketoconazole), take this product at least 2 hours after the antifungal drug.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen, ketorolac or naproxen). These drugs are similar to salicylate and may increase your risk of side effects if taken together. However, if your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: fever, fast/pounding heartbeat, severe dizziness, seizures, slowed/shallow breathing, unusual excitement.


Do not share this medication with others.

Missed dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Important note

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Information last revised May 2024.

Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.