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Antihistamines and Sleep Problems


Antihistamines, often used for relief of allergies, are sometimes prescribed to help people sleep. Examples of antihistamines are diphenhydramine (such as Benadryl) and doxylamine (such as Vicks Nyquil). Side effects may include daytime sleepiness, dizziness, mental sluggishness, and rapid heart rate. 1



  1. Abramowicz M (2009). Drugs for insomnia. Treatment Guidelines from The Medical Letter, 7(79): 1–5.


By Healthwise Staff
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Specialist Medical Reviewer Lisa S. Weinstock, MD - Psychiatry
Last Revised December 1, 2011

Last Revised: December 1, 2011

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