Naldemedine - oral
Naldemedine - oral
This medication is used to treat constipation caused by opioid (narcotic) medication. It blocks the effect of opioids on the gut without blocking the effect on pain. Naldemedine belongs to a class of medications known as opioid antagonists.
Read the Medication Guide provided by your pharmacist before you start taking naldemedine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
Ask your doctor if you should continue using your usual medications for constipation. This medication is used only for constipation caused by opioids. Stop taking naldemedine when you stop using opioid pain medication unless otherwise directed by your doctor.
Tell your doctor if your condition lasts or gets worse.
Stomach/abdominal pain may occur. If this effect lasts or gets worse, tell your doctor or pharmacist promptly.
Stop taking naldemedine and tell your doctor right away if you have diarrhea that doesn't stop.
Opioid withdrawal symptoms may occur in some people. Tell your doctor right away if any of these withdrawal symptoms occur:
This drug may rarely cause a serious tear in the stomach or intestinal wall (perforation). Stop taking this medication and get medical help right away if any of these very serious side effects occur:
In the US -
Before taking naldemedine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Other medications can affect the removal of naldemedine from your body, which may affect how naldemedine works. Examples include enzalutamide, lumacaftor/ivacaftor, mitotane, rifamycins (such as rifampin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone), among others.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others. Sharing it is against the law.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Information last revised March 2018.
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