Deferiprone - oral
Deferiprone - oral
This medication may rarely cause a very serious low white blood cell count, which increases your risk of serious, possibly fatal infections. To lower your risk, your doctor will check your blood counts with a blood test before and regularly during treatment. Get medical help right away if you develop any signs of infection such as fever, persistent sore throat, chills, or flu-like symptoms.
This medication is used by people with a certain type of blood disorder (thalassemia) who have too much iron in the body, caused by repeated blood transfusions. Blood transfusions help people with blood disorders but they also bring extra iron into the body. It is important to get rid of the extra iron because high levels of iron can cause health problems (such as heart failure, liver disease, diabetes, delayed growth in children). Deferiprone is used if you have trouble taking other traditional iron-removal medications or you continue to have high iron levels after taking other iron-removal medications.
Deferiprone belongs to a class of drugs known as iron chelators. It works by attaching to iron which helps your body pass the extra iron out in the urine.
Read the Medication Guide provided by your pharmacist before you start taking deferiprone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually 3 times a day (morning, midday, and evening). Taking this medication with food may help lessen nausea.
If you are using the liquid form of this medication, also read the Patient Instructions for Use. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. After you swallow each dose, mix some water in the measuring device/spoon and drink the mixture.
Take this medication 4 hours apart from products that may bind to it, decreasing its effectiveness. Ask your pharmacist about the other products you take. Some examples include antacids, vitamins/minerals (such as those containing iron, aluminum, zinc), among others.
The dosage is based on your medical condition, weight, and response to treatment (including laboratory test results). Your treatment may need to be adjusted or stopped if you develop serious side effects. Follow your doctor's instructions carefully. Keep all medical/laboratory appointments.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
See also Warning and How To Use sections.
Nausea, vomiting, stomach/abdominal pain, or joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
This medication may cause your urine to turn a reddish-brown color. This effect is harmless and will disappear when the medication is stopped.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:
In the US -
Before taking deferiprone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.
It is unknown if deferiprone passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.
See also How To Use section.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vision problems, weak muscles, unusual/slowed movements.
Do not share this medication with others.
Laboratory tests (such as liver function tests, complete blood counts, iron (ferritin) and zinc levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. For the liquid, store it only in the original container and carton to protect it from light. After the bottle is first opened, throw away any unused liquid after 35 days. Keep all medications away from children and pets.
Information last revised June 2018.
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