vancomycin 750 mg/150 mL in diluent combination IV piggyback

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Medication name

Generic name:
Vancomycin (with peg-400, nada) - injection

Pronunciation
(VAN-koe-MYE-sin)

Warning

Vancomycin injection solution with PEG-400 and NADA is not recommended for use during the first or second trimester of pregnancy. PEG-400 and NADA may harm an unborn baby. Tell your doctor if you are pregnant, think you may be pregnant, or plan to become pregnant. Your doctor can prescribe another vancomycin product that can be used during pregnancy.

Uses

Vancomycin is used to treat serious bacterial infections. It is an antibiotic that works by stopping the growth of bacteria.

How to use

This medication is usually given by injection into a vein as directed by your doctor. Each dose should be injected slowly over at least 1 hour. The dosage and length of treatment are based on your medical condition, labs, weight, and response to treatment.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Infusion reactions may happen during the infusion of this drug if this drug is injected too fast. Tell your doctor right away if you have any symptoms of infusion reactions such as flushing of the upper body, dizziness, or muscle pain/spasms of the chest and back. Your doctor may slow down or stop your treatment for some time.

For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.

Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Side effects

See also How to Use section.

Pain, redness, and tenderness at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • hearing problems (such as ringing in the ears, hearing loss)
  • signs of kidney problems (such as change in the amount of urine)
  • easy bleeding/bruising
  • vision changes (such as blurred vision, decreased vision)

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop:

  • diarrhea that doesn't stop
  • abdominal or stomach pain/cramping
  • blood/mucus in your stool

If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

  • fever that doesn't go away
  • new or worsening lymph node swelling
  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using vancomycin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • kidney problems
  • hearing problems
  • stomach/intestinal problems (such as colitis)

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Vancomycin may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using vancomycin before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be at greater risk for infusion reactions, especially when this medication is injected too fast.

Older adults may be at greater risk for kidney and hearing problems while using this drug.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using this product. Vancomycin solution with PEG-400 and NADA may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. See also Warning section.

This medication passes into breast milk. Consult your doctor before breastfeeding.

Drug interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is:

  • cidofovir
Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669.

Notes

Lab and/or medical tests (such as kidney function, vancomycin blood levels, blood cultures, complete blood counts, hearing tests) should be done while you are using this medication. Keep all medical and lab appointments.

Missed dose

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.

Storage

Store this medication at room temperature in its outer pouch until ready to use. If you remove the outer pouch, the product should be used within 28 days. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Important note

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Information last revised November 2024.

Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.